TCMDC-123812 and 123794 and intermediates sent to GSK Tres Cantos
Community malaria research community, general open research I have just packaged up TCMDC-123794 (PMY 11-2) and -123812 (PMY 10-2) along with the parent acid (PMY 8-2), ester (PMY 6-1), aldehyde (PMY...
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Reacting to the first set of biological results
Community malaria research communitySubject Request for HelpWe have received encouraging biological results for the analogues we sent for testing before Christmas. Mat has discussed this here on TSL...
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Near-Neighbour Round 2 SAR
The first results of bio-data for the 2nd round of compounds is back from the Avery group and Mat has summarised the results in his post here on synaptic leap and on Google+. We are seeing some very...
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Exciting times: First in vivo submissions
Community malaria research communitySubject Request for HelpIt's exciting as usual on the project. We've submitted the three compounds for in-vivo oral evaluation in a mouse model. The original hits...
View ArticleMetadata for labtrove
Community general open researchThere's something that we've been neglecting on our Labtrove ELN entries so far that we should probably deal with. Metadata. It would be great to add some more of this to...
View ArticlehERG, Gametocytes, Metabolism, In Vivo
Community malaria research communitySubject Results I've been on holiday for a couple of weeks and it's nice to come back to a whole load of biological data. Before I left I submitted compounds for...
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Single crystal X-ray
Community malaria research communitySubject Technical NoteWe've just had a single crystal x-ray structure back for OSM-S-9 (PMY 35-1) confirming which isomer of the product we've been making.The...
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ChEMBL-NTD actives
Community malaria research communityI thought I would just quickly summarise some of the hits that come up in ChEMBL-NTD for the core structures of the compounds we're working with at the moment. The...
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A quick compound update
Community malaria research communitySubject ResultsTomorrow we will be having an open chat with anyone who wants to pitch in about which compounds we should be making for the next round of testing....
View ArticlePharmacokinetics
Community malaria research communitySubject ResultsPreviously, we found that we had no efficacy for the compounds tested in our in vivo plasmodium berghei study. Until now we haven't had our...
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